Mutation bias in evolution: climbing Mount Probable (Ep 97)
Big Biology
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The Importance of Variation in Selection
In evolutionary quantitative genetics, mutation is actually in the background a little bit and you're talking about standing variation. But if the sand grains get too big and they're big chunks, right, now you need to have a theory for what's the character and timing of appearance of those chunks. And that moves you into this other realm. The problem was Haldane and Fisher weren't thinking about the introduction process. So that theory of evolution by mutation pressure is not really very important for understanding ongoing evolution. It helps to understand things like genetic diseases.
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