A New Type of Antichristper System in Viruses

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The hosts discuss a brand new type of Antichristper system in viruses that helps them evade destruction by the CRISPR-Cas immune system. They explore how viruses have evolved countermeasures, including mutation and anti-CRISPR proteins, to avoid recognition and inhibition by the gene scissors. The chapter also highlights the discovery of RNA molecules that mimic host CRISPR RNA guides and effectively block the CRISPR system.

In this episode:

00:47 An RNA-based viral system that mimics bacterial immune defences

To protect themselves against viral infection, bacteria often use CRISPR-Cas systems to identify and destroy an invading virus’s genetic material. But viruses aren’t helpless and can deploy countermeasures, known as anti-CRISPRs, to neutralise host defences. This week, a team describe a new kind of anti-CRISPR system, based on RNA, which protects viruses by mimicking part of the CRISPR-Cas system. The researchers hope that this discovery could have future biotechnology applications, including making CRISPR-Cas genome editing more precise.

Research article: Camara-Wilpert et al.

09:05 Research Highlights

Carved inscriptions suggest a queen named Thyra was the most powerful person in Viking-age Denmark, and the discovery of a puffed-up exoplanet that has just 1.5% the density of Earth.

Research Highlight: Runes on Viking stones speak to an ancient queen’s power

Research Highlight: ‘Super-puff’ planet is one of the fluffiest worlds ever found

11:38 Modelling the future of Greenland’s ice sheet melt

Climate-change induced melting of Greenland’s vast ice sheet would contribute to 7m of sea level rise. But it has been difficult to calculate how the ice sheet will respond to future warming. This week, a team suggest that abrupt ice loss is likely if the global mean temperature is between 1.7 °C and 2.3 °C above pre-industrial levels. Keeping temperature rise below 1.5 °C could mitigate ice loss, if done within a few centuries, but even a short overshoot of the estimated threshold could lead to several metres of sea-level rise.

Research article: Bochow et al.

17:50 Briefing Chat

A massive reproducibility exercise reveals over 200 ecologists get wildly-diverging results from the same data, and how melting simulated lunar-dust with lasers could help pave the Moon.

Nature News: Reproducibility trial: 246 biologists get different results from same data sets

Nature News: How to build Moon roads using focused beams of sunlight

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