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First10EM Journal Club: January 2025

Broomedocs POdcast

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Evaluating Tranexamic Acid in Postpartum Care

This chapter explores the WOMAN2 trial, which examines the effectiveness of Tranexamic Acid (TXA) in preventing postpartum hemorrhage in women with anemia, revealing no significant differences from placebo. The discussion highlights the complexities of clinical trial methodologies, concerns about measuring adverse outcomes, and the critical need for sound clinical judgment in emergency situations. Additionally, the chapter critiques a recent trial on TXA for brain hemorrhages, emphasizing the importance of relevant outcome measures and the implications of previous research.

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