The Risk of Compensation Theory for Submassive PE Patients

There were zero intracranial hemorrhages in either study arm. Only one fatal bleed occurred in a patient randomized to Heparin alone. Do you think that this is a reflection of a highly selected study population? And that maybe we're seeing artificially low rates of bleeding complications, or is this something else? No, this is absolutely. I think what happened here is that the trial was stopped after the interim positive analysis. So because interim analysis showed such a drastic difference in the outcome, trial was stopped earlier.