Understanding Cytokine Release Syndrome

Have you stumbled onto the haematology ward only to discover patients on bizarrely named BiTE & CART therapy? Why are we giving patients CARTs? Do they come with a horse?  Why does everyone freak out when these patients are febrile? Why is everyone so hung up about handwriting? What are these weird drugs? 

It's OK – we are here once more to demystify the acronyms – and help you know what we are giving, why we are giving it and how to manage complications of Bi-Specific and CAR-T therapy! 

TIMESTAMPS

3:48 - Intro to BiTEs  
5:26 - Intro to CAR-T  
8:27 - Examples of BiTEs  
16:36 - CAR-T Collection + Production  
18:44 - Examples of CAR-T Products  
19:35 - Similarities and Differences between BiTEs and CAR-T  
23:24 - Cytokine Release Syndrome (CRS)  
30:23 - Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS)  
39:29 - Treatments for CRS  
45:52 - Treatments for ICANS  
50:01 - Take Home Messages  

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