How Glycolytic Intermediates Produce Methylglyoxal

• Why glucose and fructose are not the primary drivers of AGE formation

• Whether blood sugar spikes cause glycation

• How fats and ketones can cause glycation

• What’s really responsible for glycation in type 2 diabetes

• Whether fructose causes more glycation than glucose

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Click here to check out the show notes:
https://www.jayfeldmanwellness.com/eb-137-what-really-causes-glycation-is-sugar-really-the-problem/

Timestamps:

0:00 – intro 

0:46 – common beliefs about carbohydrates and glycation 

2:35 – what are glycation and advanced glycation end products? 

6:57 – the process of glycation from glucose 

9:30 – is sugar the only source of AGEs? 

15:00 – primary drivers of glycation: dicarbonyls 

19:30 – how fatty acids, amino acids, and ketones cause AGE formation 

21:23 – how increased gluconeogenesis on low-carb diets increases AGE formation 

22:53 – glucose metabolism produces very few glycation products in the context of a healthy metabolism 

25:33 – omega-6s form AGEs more than 10x faster than glucose 

28:24 – the role of ALEs (advanced lipoxidation end products) in glycation and chronic disease 

30:36 – whether blood sugar spikes cause glycation 

38:52 – whether fructose causes more glycation (or fructation) than glucose 

47:05 – can glycation from fructose (fructation) be measured, and does this matter? 

52:06 – problems with research looking at fructose’s AGE formation in animal models