Macrophage Metabolic Rewiring Improves Heam Suppressed Epharocytosis and Tissue Damage in Sickle Cell Disease

The outcomes are very impressive. There is a lingering concern about infections and the potential long-term effects of this approach on the growth and development of young patients. Another concern is the risk of developing new malignancies, either hematological or solid tumors. Future studies should investigate whether a regimen used for HLA haploidentical transplants in patients with aplastic anemia could also be used for patients receiving HLA identical transplants.