How Do You Set a Border With Someone in Your Family?

How should we deal with irrational or difficult people? And what are some good strategies for establishing healthy boundaries with such people in our lives? As a very pro-social podcast, we realized this may be our weakness after we talked to Chrissy Stroop in Episode 618. Chrissy, a trans woman, told us she did not feel it her responsibility to keep toxic or unsupportive people in her life, and Bart pushed back because he feels building bridges across such divides is so important. Where should the healthy limits of our empathy, tolerance and relationship-building be set?