S4E05: Antibiotic Resistance: A Call to Arms
Two Scientists Walk Into a Bar
00:00
Using Small Molecules to Target Gram Negative Bacteria
The molecules are quite big compared to what you would sit like speran molecule, there's something like that. But the one advantage that that brings with it is that this part, the northwest corner of our molecules, doesn't really know much about what's happening at the southeast corner of the molecule. And so what we're able to do is swap in the pieces that work best in each of those sort of quadrants and put them together, and then the the function is adjective. That was actually something that we don't usually see on a small molecule programme. We started out with these molecules that had a function against a gramd positive bacterium that we weren't very concerned with.
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