RUNX1 isoform imbalance drives ML-DS, VWF-binding RNA aptamer for hemophilia A treatment, and EZH1/2 inhibitor valemetostat in relapsed/refractory ATL
Blood Podcast
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RUNX-1 Is Associated With TAM and MLDS Pathogenesis
Trisomy-21 has been implicated in the evolution of TAM to MLDS, though its exact role is still opaque. Several chromosome 21 genes have been reported to play a part in leukemogenesis. Researchers found that expression of RUNX-1A was elevated in MLDS and Trisomy-21 cell samples.
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