Listen to a blog summary of a recent research paper published in Volume 13, entitled, "A novel group of genes that cause endocrine resistance in breast cancer identified by dynamic gene expression analysis."
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Hormones can cause tumor growth in some subtypes of breast cancer. Endocrine therapy, also known as hormone therapy, is a type of cancer treatment that removes or blocks the hormones which fuel breast cancer growth. This treatment is often given as adjuvant therapy after breast cancer surgery to lower the risk of cancer reoccurrence. In some cases, endocrine therapy may be used as a first-line treatment for hormone receptor-positive breast cancers, such as estrogen receptor-positive (ER-positive) breast cancers. However, ER-positive tumors frequently become unresponsive to endocrine therapy, and tumor regrowth can occur after treatment. The underlying causes of endocrine resistance are mostly undetermined.
“Endocrine therapies have been successful at improving cancer outcomes; however, the development of endocrine resistance, or resistance to inhibition of ER actions, remains a roadblock in breast cancer treatment.”
Recently, researchers—from UTHealth Houston, University of Chicago, University of Texas MD Anderson Cancer Center, and the University of Houston—used a new statistical and computational pipeline method of analysis to study the dynamic behavior of gene expression during the development of endocrine resistance in breast cancer. Their trending research paper published in Oncotarget on April 06, 2022, is entitled, “A novel group of genes that cause endocrine resistance in breast cancer identified by dynamic gene expression analysis.”
Full blog - https://www.oncotarget.org/2022/04/14/trending-with-impact-genes-identified-in-endocrine-therapy-resistance/
DOI - https://doi.org/10.18632/oncotarget.28225
Correspondence to - Michihisa Umetani - mumetani@uh.edu, and Vahed Maroufy - Vahed.Maroufy@uth.tmc.edu
Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28225
Keywords - breast cancer, triple negative breast cancer, gene expression profiling, endocrine resistance, gene clustering
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