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Ep. 41: “Chromosomal Disorders” Featuring Dr. Eirini Papapetrou

The Stem Cell Podcast

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Exploring Chromosomal Deletions in Blood Disorders

This chapter examines the use of isogenic human pluripotent stem cell models to study the genetics of blood diseases, particularly focusing on mild dysplastic syndrome. The discussion highlights methodologies for deriving induced pluripotent stem cells and the complexities of chromosomal deletions, especially on chromosome 7Q, and their correlation with disease severity. By addressing the transition from myelodysplastic syndromes to acute myeloid leukemia, the chapter underscores the challenges in understanding genetic mutations through patient-derived cells.

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