AI Meets Biology: Transforming Research

This chapter explores the intersection of artificial intelligence and biology, highlighting innovative research and foundational challenges in the field. It discusses the complexities of drug discovery and the critical need for causal understanding in biological data, emphasizing the role of AI in this transformation. The conversation delves into methodologies like single-cell transcriptomics and in silico modeling, reflecting on the evolving practices within computational biology.

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In this episode of The Cognitive Revolution, Nathan explores the cutting-edge intersection of AI and biology with Stanford assistant professor Brian Hie. Discover how AI is revolutionizing our understanding of biological systems and creating new possibilities for interventions. Brian discusses his groundbreaking papers on hybrid AI architectures, the surprising capabilities of language models trained on DNA sequences, and AI-guided evolution of antibodies. Join us for an insightful journey into the future of AI in biology, touching on biosecurity, drug discovery, and the challenges of interpreting AI models in biological contexts.

Links :

Brian Hie : https://x.com/BrianHie

Scanorama paper

Mechanistic Design and Scaling of Hybrid Architectures

Sequence modeling and design from molecular to genome scale with Evo

Unsupervised evolution of protein and antibody complexes with a structure-informed language model

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CHAPTERS:

(00:00:00) About the Show

(00:00:22) About the Episode

(00:03:22) Introduction and Overview

(00:03:55) AI for Biology: Big Picture

(00:05:49) Challenges in Biology and Drug Discovery

(00:08:36) Scanorama and Single Cell Transcriptomics

(00:10:27) Brian's Research Identity

(00:13:00) Mechanistic Design of Hybrid Architectures

(00:14:52) Evo: DNA Language Model (Part 1)

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