The APOE4 Phenotype and Cholesterol

The optimal total cholesterol for longevity is somewhere in the mid-200s. Once your total cholesterol level gets under 200, your all-cause mortality starts to double. The body has a whole bunch of systems to make sure it can regulate cholesterol levels. And we're killing people trying to get their cholesterol levels low.

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My guest this week is Dr. Dayan Goodenowe, PhD. of Prodrome Sciences.

In this episode, Dr. Goodenowe and I discuss plasmalogens; what are plasmalogens, the fascinating research and case studies around antiaging and quicker recovery, why plasmalogens decline with age, the connection between myelination and brain development, various conditions plasmalogens can support; particularly in degenerative diseases like Alzheimer’s, MS, Parkinson’s and other neurological conditions, and how you can improve your plasmalogen levels through diet and supplementation. Dr. Goodenowe does an incredible job of breaking down the science of APOE genetic variations and the importance of cholesterol, as well as if it is possible to prevent TBI’s.

I’m incredibly excited about the use of plasmalogens–not just for recovery, general cognition, and longevity, but also for the potential to support prevention and addressing of so many common debilitating conditions from autism to Alzheimer’s, cancer, and more. Plasmalogens are found in various areas of the body and they account for about 20% of our brain’s total weight, peaking in our 30s and 40s, but substantially declining by our 70s. The good news is we can restore levels (and also test). We have a lot to cover, including prenatal and postnatal care! Let’s dive in!

Learn more about plasmalogens at here and use discount code NAT25 on your order.

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Episode Takeways

[09:30] If something is broken, fix it.. Even if you don’t “feel” anything...

[18:00] What are plasmalogens?..

[39:00] Why are plasmalogens supportive for TBIs and prevention?..

[46:45] Do plasmalogens support mitochondria?..

[49:52] Can plasmalogens reduce risk for those with APOE & APOA variations…

[01:10:00] Plasmalogens post TBI…

[01:14:15] The effects of overexercising...

[01:18:00] When should children or pregnant women take plasmalogens?..

[01:20:00] What blood tests should we do and when?

[01:25:20] What types of foods increase plasmalogen production?..