2min chapter

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#123 – Manolis Kellis: Origin of Life, Humans, Ideas, Suffering, and Happiness

Lex Fridman Podcast

CHAPTER

Is There a Level of Selection Going On?

Every gene operates at the level of its internal cellular environment. If I take a gene from say an African individual and I put it in a European context, will it perform the same way? Probably not because there's a cellular context of thousands of other genes that that gene has coevolved with. So basically, if you look at Neanderthal genes, for example, which happened long after that out of Africa event, there's incompatibilities between Neanderthal genes and modern human genes that can lead to diseases.

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