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Ep. 77: “Computational and Translational Immunology” Featuring Dr. Caleb Lareau

The Immunology Podcast

CHAPTER

Preventing Lung Injury in Influenza with Necropatosis Blockade

The chapter explores the role of necroptosis in lung injury during severe influenza, detailing the signaling pathways involved and the use of inhibitors to regulate cell death. It highlights a newly engineered drug that selectively inhibits necroptosis, demonstrating its effectiveness in protecting against lethal viral infections like influenza. The discussion also touches on the differences in treating COVID-19 and ARDS, emphasizing the importance of understanding the thrombosis component in COVID-19 and alternative treatments beyond ventilators.

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