2min chapter

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Ketamine: Benefits and Risks for Depression, PTSD & Neuroplasticity

Huberman Lab

CHAPTER

The Dissociative Third Person of Self Effect of Ketamine

The dissociative effects of ketamine are so profound that I thought I'd spend a minute or two explaining what likely causes that dissociative third person of self effect. And in so far as we know, it has to do with an uncoupling of certain brain circuits in particular neocortical brain circuits. It seems that when people take ketamine or phancyclidine PCP, there's an uncoupled of those networks,. That starts to create a different dominant rhythm in the brain which is associated with a dreamlike state.

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