65 - Taking Things to Heart
The Curious Clinicians
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Laminin and Heart Valve Damage
Laminin is a protein found in basement membranes and cardiac valves contain a lot of laminin. Laminin has structural similarities to myosin, so it's not surprising that there's evidence that laminin also plays a role in rheumatic heart disease. A 2000 JCI study found that this anti-eustreptococcal myosin antibody, it bounced strongly to laminin in the basement membranes of formal and fixed mitral valves.
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