Is Nanoparticle Delivery a Last Barrier to Endocytosis?

The cell has other ways of taking up extracellular material. Is it worth, or have people explored targeting other endocytosis pathways like Kaleoli or macropenocytosis? Or do we actually know for most nanoparticles how they enter the cell? A lot may depend on what you're delivering, right? If you're delivering DNA, rather than say RNA, you want to go to the nucleus.