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Ep. 83: “Biomolecular Sensors” Featuring Dr. Shana Kelley

The Immunology Podcast

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Unraveling TLR Signaling and Immune Modulation

This chapter explores the intricate molecular mechanisms of toll-like receptor (TLR) signaling and its significance in innate immunity, highlighting proteins such as MyD88 and their complex cellular structures known as mydosomes. The discussion further connects immune modulation to cancer and pregnancy through the immune checkpoint molecule B7H4, examining its effects on tumor tolerance and fetal development. Additionally, it investigates the role of BRD4 in ovarian cancer, emphasizing the potential for targeted therapies through epigenetic inhibition.

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