Why does B12 damaged by nitrous oxide require megadosed folic acid rather than normal levels of folate? | Masterjohn Q&A Files #265
Mastering Nutrition
The Effects of Vitamins and Minerals on Metabolic Function
One plausible explanation is that not only did they have a methyl trap but they had a transient down regulation of methylation reactions which reversed when they started supplementing the B12. I suspect folic acid probably would have worked. The new version has a comprehensive guide to interpreting the Genova methylation panel. You can pick up your copy at chrismasterjohnphd.com.
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