The Role of Invariant Chain in Lupus Research

This chapter explores a study on mouse models that investigates the effects of invariant chain deletion on immune responses, particularly in relation to lupus. It discusses how the absence of invariant chains affects T cell education, antigen presentation, and the development of self-reactive T cells. The findings indicate significant implications for understanding autoimmune conditions like lupus, emphasizing the need for further research into the role of invariant chains and their relationship with immune tolerance.