In this episode, Jay interviews Leslie Kenny, a world-renowned physiologist and Emeritus Professor of Physiology at the University of Oxford. At the age of 58, Leslie has managed to completely reverse her autoimmune conditions and achieve a biological age of 21.

Their conversation covers the importance of autophagy and the important role that spermidine plays in processes related to cellular maintenance and renewal. They also describe the benefits of spermidine for things like hair health, skin pigmentation, hormonal balance, and immune system rejuvenation.

Tune in if you want to better understand the role of spermidine in biological functions, and learn how spermidine supplementation could enhance your longevity and vitality.

"Spermidine addresses a minimum of 9 out of 12 hallmarks of aging, including telomere length and mitochondrial dysfunction, and helps us avoid cancer and cardiovascular disease."

– Leslie Kenny

What You'll Learn From This Episode

Autophagy and Cell Renewal – The importance of this self-cleaning process for cell maintenance and longevity, especially for heart cells.
Benefits of Spermidine – How spermidine helps with everything from cardiovascular disease to hormone regulation to hair health and regrowth.
Synthetic vs. Natural Spermidine – Risks associated with synthetic versions of spermidine and the irrefutable benefits of food-derived sources.
Impact of Spermidine on Aging – How spermidine targets multiple hallmarks of aging and rejuvenates immune cells and cardiac cells, leading to improved health and vitality.
Hormonal Balance and Spermidine – When it comes to hormone optimization, research suggests spermidine has broad-reaching impacts for both men and women.

Key Moments In This Conversation

00:00:00 - Introduction

00:03:50 – Autophagy And Its Role In Aging

00:08:38 – Understanding Age Regression

00:12:20 – Importance of Hormone Optimization For Women

00:19:08 – Modern Challenges of Hormone Optimization

00:22:56 – Synthetic vs. Food-derived Spermidine

00:27:06 – Spermidine For Hair Health & Regrowth

00:35:29 – Dosage Recommendations For Spermidine Supplementation

00:42:03 – Importance Of Slowing The Aging Process

00:45:46 – Positive Impact of Spermidine On The Immune System

00:50:00 – Closing Thoughts And Leslie’s Resources

Guest Bio

Leslie Kenny is an Oxford-based entrepreneur with a diverse educational background, having graduated from Berkeley and Harvard Business School. Her journey towards becoming a health and longevity expert was catalyzed by her personal health challenges, including lupus, rheumatoid arthritis, and Hashimoto's at the age of 30.

Through embracing holistic health practices and launching Oxford Healthspan, a high potency spermidine supplement, Leslie has not only reversed her autoimmune conditions but also achieved a remarkable biological age of 21 at the chronological age of 58. Her personal transformation is living proof that individuals can improve their health and vitality with age.

Learn more about Leslie and her work at www.oxfordhealthspan.com.

Jay Campbell Products & Resources

👉 Pick up my newest international best-selling book on Using Peptides: Optimize Your Health with Therapeutic Peptides: Extend Your Life by Becoming More Muscular, Leaner, Smarter, Injury-Free and Younger https://www.amazon.com/dp/B0BSVL2X6Z/...

---------------------------------------------

✅ Ready to Let Me Help You Optimize Your Body, Mind, Heart and Soul?

👉 https://jaycampbell.com/start-here/👈

📧 Subscribe to Jay's email list and Raise Your Vibration!

👉 http://join.jaycampbell.com 👈

Maybe you are dabbling in peptides but want to learn how to master their use?

If you can answer ‘yes’ to either of those questions, I just released this FREE must-have E-book: The Top 10 Mistakes People Make When Starting Peptides

Avoid the trial and error experienced by 95% of Peptide users and learn how to supercharge your results.

Grab Yours Now: https://www.thepeptidescourse.com/10-...

---------------------------------------------

If you're using Therapeutic Testosterone now or suffering from the symptoms of Low Testosterone, I just released this FREE must have E-book: Top 10 Questions to Ask Your Doctor About Testosterone

It is critically important for you to ask the right questions and for your Doctor to have the right answers before going ALL IN on the most profound treatment in the world of optimized health, Testosterone Optimization Therapy.

As a HUGE Bonus: I AM giving away the #1 selling book of all time on using Therapeutic Testosterone (The TOT Bible) in both PDF and audio format FREE! (Please wait for the email to show up with your download links.)

Grab Yours Now: https://www.totdecoded.com/10-questions

---------------------------------------------

These Are Products I Believe In And Use!

Limitless Life Nootropics (Peptides) The ONLY Reliable Source For Ultra-Pure Therapeutic Peptides: Use code Jay15 to take 15% off your order http://limitlesslifenootropics.com/jayc

Fat Loss Stack | Healing Stack | Longevity Stack | Healing Stack http://limitlesslifenootropics.com/Ja...

NAD REGEN from Biostack Labs is a revolutionary NAD+ Supplement that supports better cellular energy production, improves cognitive function, and promotes healthy aging. Save 10% on your order at https://biostacklabs.com/jay.

VibraGenix (Acoustic Wave Vibrational Technology) The VibraGenix Elite Platform harnesses the power of vibration to hasten your path to elevated consciousness and wellness. http://vibragenix.com/jayc/

Zeroats Sugar FREE Oatmeal The ONLY amazing tasting oatmeal on the market that has ZERO, ZILCH, NADA sugar. https://www.zeroats.com/jayc.

October 23, 2025

Letters from an American

Intro

The AI-powered Podcast Player