13min chapter

The Immunology Podcast cover image

Ep. 65: “Primary Immunodeficiency Disorders” Featuring Dr. Siobhan Burns

The Immunology Podcast

CHAPTER

Xenotransplantation: Modifying Pigs for Organ Donation

This chapter discusses the use of pigs as models for humans in medicine, particularly for surgery, orthopedics, and transplantation. It explores the challenges and incompatibilities related to transplantation, including pig tissue immunogenic properties and the potential activation of endogenous retroviral sequences. The chapter also highlights a study that focused on genetically modifying pigs to improve the success of xenotransplantation by reducing complement activation and the need for immunosuppressive drugs.

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