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Hunger, weight loss and obesity | Stephan Guyenet, PhD

The Proof with Simon Hill

CHAPTER

The Personal Fat Threshold Explains Type 2 Diabetes and Insulin Resistance

If you're adipose tissue is functioning well, even at a high level of fat mass, it's still going to be effective at containing that excess energy. People who are like this have a lot of subcutaneous fat, fat under the skin,. Not a lot of visceral fat, fat in the abdominal cavity, under your abs. Some of those people are actually quite insulin sensitive. So they just have a really high personal fat threshold. And on the other side of things, you have people who have lipodistrophe, which is a condition where you actually can't put fat on and your fat cells are genetically dysfunctional.

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