The Insolent Hypothesis

Immunodeficiency, Is Alzheimer's Preventable, Ice Hockey / Sleep, BPPV, Imodium

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News topic du jour:

Too Good To Check: A Play In Three Acts

1. Immunodeficiency [20:52]

Mary says:

Hi Robb and Nicki!

I love your podcast and have been listening on and off for a few years.  You are the only health based podcast that I still listen to since everyone has gone crazy this past year and I highly value all the work that you are both doing!

So.... my husband has described me as the most sickly health fanatic that he has ever met.  I catch every cold, have frequent sinus, bronchitis, yeast infections, strep, skin rashes, stomach flus, bouts of fatigue and dizziness.  I have tried every diet out there to feel better.  I have your books Wired to Eat and The Paleo Solution, so I am familiar with carb testing and using a glucose meter. If I am active, running (10k plus or hard intervals etc) and lifting weights, I know that fast acting carbs like sugar are needed or my recovery will suffer.  For days.  I use a manual glucose monitor to track this.  Intermitent fasting and keto are both a no go for me as I will have disrupted sleep, poor performance and fasting blood sugar levels under 4mmol/L, and with keto my ldl levels go up. I know everyone is so sick of hearing about covid but it plays into my question.  I had been low carb for years, and in the most recent year eating closer to carnivore with fruit and local raw honey.  I have also had chronic low ferritin for years, even eating steak fried in a cast iron pan once or twice a day and avoiding grains and dairy.  I am a personal trainer and runner and was very fit.  I got covid October 30 to be exact.  It knocked my socks off and I have never been the same.  Energy crashes, days of extreme fatigue and dizzy spells, limited running performance. I have not worked full time since.  I was referred to a post covid pulminary clinic and I am showing slight blockage in my lungs.  They were testing for autoimmune and I surprised them with underimmune, low immunoglobulin IgG. We have recently been in contact with previously unknown family and found out that my 1/2 aunt has primary immunodeficiency.  I am on the wait list to see an immunologist but it could be months before I get seen.  I am at a loss at what to do now.  I have given up on paleo etc mostly out of dispair that anything is going to help.  What was working diet wise (the near carnivore) prior to having covid no longer works.  I did the DNA fit after listening to that episode of your podcast and it has come back recomending moderate carb and protien, no celiac etc.  Besides my Low IgG and ferritin all my bloodwork is great.

Not sure where to go from here, what questions I should be asking Drs, should I redo the carb testing as my body seems to have changed?  Should I join your group for the upcoming reset?

Sorry that this has been so long and rambling!  I would greatly appreciate any insight that you may have.

Thank you,

Mary

2. Is Alzheimer's preventable? [29:18]

Edrie says:

Hi Robb and Nicki, hope you guys are doing well. Thanks for all that you do, your podcast is something I look forward to every week. I have a subject I'd love your insight on: Alzheimer's Disease, specifically the prevention of it. My dad was diagnosed about 5-6 years ago (at age 64ish) and we just had to move him to a memory care facility because he needs 24 hour a day care. It's heartbreaking and terrifying to watch a loved one slip away and now to see all the advanced stage residents, a glimpse of what's to come. It's too late to delay or improve my dad's disease, but I am very interested in not spending my senior years living that way. Aside from maintaining a healthy diet, exercise, sleep, and managing stress (which are all things I prioritize), is there anything folks can do to prevent Alzheimer's? Are there any studies or research that you know of that you could point me toward?

Thank you again,

Edrie

https://www.wndu.com/content/news/The-good-side-of-nicotine-for-Alzheimers-patients-567810531.html#:~:text=%22And%20nicotine%20can%20help%20imitate,improvements%20in%20attention%20and%20memory.

The End of Alzheimer's Program

3. Ice hockey / sleep [31:47]

Jator says:

I have hockey practice typically 20:45-22:00 3 days a week. This is a requirement and I sleep (obviously) terrible on those nights, also shows objectively on my Oura ring.

Not in a place ready to give up hockey BUT would love your thoughts on how to mitigate the stress response as much as possible to catch a decent night of sleep.

Thank you for considering

Huberman Lab - Science of Muscle Growth, Increasing Strength & Muscular Recovery

4. BPPV [37:22]

Carla says:

I have recurring BPPV. I am wondering if you have any suggestions in terms of diet and exercise that will help with this condition? I have asked my doctor and she says I just have to live with it. I have done the Epley maneuver several times which gives me temporary relief but nothing lasting. I am a 51 yo female and about 30 lbs overweight. Any insight you could provide would be welcome. Thank you for all you do!!

Benign paroxysmal positional vertigo

5. Imodium [39:56]

Tom says:

I’ve heard you talk about low dose Imodium to help with loose stools.  I take 1/2 of a pill each morning, which is 1/4 of a dose.  Are there any long term side effects to this.  Have recently switched to carnivore due to unresolved issues with Keto.  Did the keto masterclass last year and saw great improvements, thanks for that and the content you put out on the regular.  Tom-Full Time RVer.

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