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The Gene-Editing Revolution with Verve Therapeutics
FYI - For Your Innovation
Is There a Difference Between Humans and Heterozagus F H?
We've done a pretty extensive programme to evaluate r l and p in verve one o one, and actually also our galnak l n ps in models of wild type heterozigus f h and homozigu f h. Homozigus is really ase case. If you totally lack the l d l receptor, then lipinana particles will not be taken up very well. But in the wild type, in the heterozigUS, you have enough l d l receptors to still take up the banana particles efficiently and deliver the r and a pay load. We think that we're getting plenty o a base editor into into these livers in heter zag
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