Dysbiosis and the Microbiome

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The most compelling data we have on this is there are germ-free mouse models of colitis. And they don't develop colitis without a microbiome, but their conventional counterpart that's fully colonized will develop over a colitis. There's often like signatures of certain bacteria that tend to be prevalent when you have flares or when you have disease. It also makes me wonder, early in our life at age one, two, or three, should we be understanding our microbiome signature so then we can track it over the course of our life.

Episode #267. Join me for a deep dive into the influence of the gut microbiome on inflammation and metabolic disease. In this fascinating exchange with Dr Suzanne Devkota, we explore the role of the gut in these conditions, shedding light on food allergies, IBD, and obesity. You’ll learn the practical tips you need to nurture a healthy microbiome, as well as gain a better understanding of what we do – and don’t – know about this incredible system.

Specifically, we discuss:

Intro (00:00)
The evolving field of microbiome research (02:13)
Gut microbe on social media (09:32)
Microbiome definition (12:48)
Why the focus on gut bacteria? (13:55)
Differences in Microbes (16:02)
Microbial shifts and adaptations (18:45)
Microbes perturbations (21:35)
Human microbiome in evolution (23:54)
Healthy microbiome and diversity (27:47)
Is the microbiome the sole driver of metabolic diseases? (33:05)
Dietary patterns and FODMAP intolerance (41:07)
Saturated fat and gut health (49:15)
Microbiome metabolites and heart disease risk (57:42)
Inflammatory bowel disease (IBD) and dysbiosis (1:02:09)
Food additives (1:12:29)
Supporting the microbiome in IBD (1:15:29)
Microbiome's interaction with fat cells (1:16:52)
Short-chain fatty acids and appetite regulation (1:29:26)
Practical tips for nourishing a healthy gut (1:31:05)
Microbiome's interaction with Polyphenols (1:38:43)
On supplements and fermented foods (1:39:15)
Factors affecting gut health beyond nutrition (1:46:22)
Outro (1:50:10)

Connect with Dr Suzanne Devkota on Instagram and Twitter. Learn more about her research at http://www.devkotalab.com/thelab.

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Enjoy, friends.

Simon

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Simon Hill, MSc, BSc (Hons)

Creator of theproof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

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