3min chapter

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#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics

Lex Fridman Podcast

CHAPTER

The Back Death Killed 30% of Europe and Africa

The human genome is that we have co-opted many of these immune genes to carry out non-immune functions. In our brain, we use immune cells to cleave off neuronal connections that don't get used. If you look at how Europe was shaped and how Africa was shaped by malaria, for example, all the individuals that carry a mutation that protects you from malaria were able to survive much more.

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