Evolutionary Implications of HFE Gene Mutations and Infections

The chapter explores the evolutionary advantage of HFE gene mutations in relation to iron absorption and its connection to infections like tuberculosis and yersinia species. It discusses the historical context of diseases such as tuberculosis and the plague, examining how genetic variations may have influenced resistance to these infections. Furthermore, it delves into the interactions of hemochromatosis with iron-loving bacteria, highlighting the increased infection risk for patients with this condition and its potential impact on athletic performance.