This was an international multi-center randomized controlled non-inferior trial conducted at 17 neonatal intensive care units in the Netherlands, Belgium, and Denmark. The babies who were included were infants with a with a gestational age at birth of less than 28 weeks. They have to have a confirmed PDA on echocardiogram with a diameter of superior to 1.5 millimeters at the smallest point. So most people will see ended up using standard doses, but there's not nothing specifically established right in the methodology.

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