To run out of something means the ter you use all of it up, and you don't have any left. So for example, if i'm trying to become a famous rock star, yes, but nobody likes my music, i'd probably give up on that too. To go off something means you stop liking it - like brad pitt is not quite as attractive any more. If your time has been taken up by other things, such as work, this could be because you've had no time for anything else. You're holding out for something when you really want it or need it... Or waiting for the next episode of luke english's podcast. Er, just hold on