20min chapter

The Proof with Simon Hill cover image

Metabolic health truths | Christos Mantzoros MD, DSc, PhD

The Proof with Simon Hill

CHAPTER

Evolution of Understanding Obesity and its Impact on Health

The chapter explores the historical evolution of perceiving obesity, drawing parallels to the perception of blood pressure as a normal variant before medical implications were discovered. It delves into the impact of obesity on various health conditions, the discovery of hormones like leptin in weight regulation, genetic predispositions in fat storage, and the risks associated with fat distribution in different body areas. The conversation also discusses methods for evaluating ectopic fat, and its link to metabolic conditions through inflammatory reactions involving macrophages.

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