ATG Plus Cyclosporin vs. Without Alkyl Combo Pack: A Randomized Clinical Trial

In this episode, we discuss the management of acquired aplastic anemia with Dr. Amy DeZern. Here are the links to some of the key articles discussed in this show:

1. Review article on aplastic anemia: 

https://www.nejm.org/doi/10.1056/NEJMra1413485

2. RCTs testing whether addition of cyclosporine to ATG improves outcomes in aplastic anemia:

https://www.nejm.org/doi/10.1056/NEJM199105093241901

https://www.sciencedirect.com/science/article/pii/S0006497120489748

3. RCT testing horse versus rabbit ATG in aplastic anemia:

https://www.nejm.org/doi/full/10.1056/nejmoa1103975

4. Single-arm study of eltrombopag in addition to standard immunosuppressive therapy in aplastic anemia: 

https://www.nejm.org/doi/10.1056/NEJMoa1613878

5. Long-term follow up of patients treated with immunosuppressive therapy and eltrombopag:

https://ashpublications.org/blood/article/139/1/34/476916

6. RACE Trial: Standard immunosuppressive therapy +/- eltrombopag in aplastic anemia:

https://www.nejm.org/doi/10.1056/NEJMoa2109965

7. Clinical and molecular determinants of clonal evolution in patients with aplastic anemia:

https://ascopubs.org/doi/abs/10.1200/JCO.22.00710