Brain Ponderings podcast with Mark Mattson cover image

How the Brain Decodes Odors and Computational Neuroethology with Bob Datta

Brain Ponderings podcast with Mark Mattson

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The Role of Osmosis in Alzheimer's Disease

In a typical mouse 10 to 30% of the neurons are going to be activated by a smell. Now you can finally kind of solve this basic problem in physiology, which is like, what is the mapping between odors and receptors? And Brad and I realized that we could actually do this in people. So we've begun doing experiments where we give human smells. And then we punch by up, see their noses do single cell sequencing and try to call the human receptors for odors. It worked the first time, we are super excited into humans.

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