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Varicella: A Primary Infection
In new lesions, this rash essentially continues to develop over the course of three to five days. Once every vesicle is crusted over, that's when someone is no longer infectious. In kids who are immunocompromised especially, but also in older teens and adults who are exposed to varicella for the first time, infection tends to be more severe. Primary infection can cause a viral pneumonia, which can be very severe or even fatal.