5min chapter

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Episode 197: The Effects of Coffee and Caffeine on Health and Performance

Barbell Medicine Podcast

CHAPTER

Is Caffeine Really a PDE5 Inhibitor?

Caffeine is a phosphodiesterase enzyme inhibitor. It blocks adenosine receptors with varying potency at each receptor. And it also increases norepinephrine release from the sympathetic nervous system. In caffeine naive individuals, so folks who previously have not consumed caffeine, you can see a transient so and short term increase in blood pressure because of the increase like sort of ejection of blood from the heart.

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