The Positives and Negatives of the GDMT Trial

The absolute risk reduction in this study is modest at like 1.2%. But when you calculate a relative risk reduction, the point estimate is 0.70. So this is a 30% reduction. The conference intervals go from as low as 0.44, so more than a 50% reduction in really bad outcome to as high as a 14% higher, 1.14. "I hate these guideline documents that just put things in boxes and tell us do this," he says.