The Effects of Insulin on A1C Normalization

A lot of the effects that we like so much with the GLP ones, the SGLT2s, I wonder how that would skew differently if we sort of looked at things today. Because it's how you get there, right? Like if you're putting someone on Metformin and lifestyle changes and their A1C normalizes, that's great. That's going to be a good outcome. But if you're hammering them with like 150 units of insulin a day to get them down, that's a much different situation. It's not just about the glucose that we know for sure, and that's why these agents, the cardiovascular outcome trials, they definitely were designed