Are Sematic Mutations Related to Aging?

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sematic mutations are known to cause cancer, which can in turn reduce life span. With a few notable exceptions, larger animals often have far lower rates of cancer than smaller ones. But this theory doesn't necessary a line with what we see in the animal kingdom. If somatic mutations are linked to aging, then something else must be going on. And now alex and his colleagues have delved into the sematic mutation rates of a range of mammals for the first time - hoping to unravelled some of these mysteries.

00:54 How Mammals’ mutation rates affects their lifespan

For biologists, a long-standing question has been why some animals live longer than others. This week a team have attempted to answer this, by measuring the rates that different animal species accumulate mutations. They show that longer-lived animals acquire mutations at a slower rate, which helps to explain why cancer risk does not scale with lifespan.

Research article: Cagan et al.

News and Views: Mutational clocks tick differently across species

07:56 Research Highlights

A clinical trial suggests a change to the treatment of a pregnancy ailment, and astronomers identify the largest known structure produced by a single galaxy.

Research Highlight: Ambitious trial inspires a rethink on a common ailment of pregnancy

Research Highlight: Even among ‘giant’ galaxies this one is record-setting

10:43 The war in Ukraine’s effects on global energy

Many European countries are dependent on Russian fossil fuels for energy production. Following Russia’s unprovoked invasion of Ukraine, these countries are looking to wean themselves off these fuels, which could have short- and long-term impacts on emissions and food production.

Feature: What the war in Ukraine means for energy, climate and food

Editorial: The EU can simultaneously end dependence on Russia and meet climate goals

Editorial: The war in Ukraine is exposing gaps in the world’s food-systems research

19:58 A new measurement of a particle’s mass hints at new physics

Last week, a new estimate of the W boson’s mass caused much excitement among physicists. The result suggests that this particle is heavier than theory predicts, a finding that could be the first major breach in the standard model of particle physics. However, measuring W bosons is notoriously tricky, and further work will be needed to confirm the finding.

News: Particle’s surprise mass threatens to upend the standard model

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