Sawbones: Grapefruits
Sawbones: A Marital Tour of Misguided Medicine
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The Enzyme That Blocks SIP-3A4
If you put something in the body that will block SIP-3A4, it's not going to break down the drugs. So they'll just stay in there. And if you keep taking them, instead of building up really high levels - which would actually decrease drug working - you're burning through it. There are a lot of things that inhibit this enzyme. There are also many things that activate this enzyme. This is at the root of some of those interactions.
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