The Risk of Bias in a Platform Trial

The third question is, did the investigators minimize risk of bias from information flow within and outside the specific platform? I think in many ways, it's relatively easy to minimize the risk of bias. What i think is very difficult to maintain is the influence of other clinical trials outside of your platform trial. Whether or not that’s likely to influence either the decision making of participants to be in your clinical trial, or whether or not the standard of care is changing due to other clinical trials occurring. And to a certain extent, this hasn't been resolved about how to deal with changing standard of care. But there are statistical methods to evaluate whether ornot the underlying control event rate changed according to