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John Ioannidis on Statistical Significance, Economics, and Replication

EconTalk

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Is a Meta-Analysis More Reliable Than a Single Study?

"I cannot answer in a black and white fashion that meta-analyses is always better than a single study," he says. "We're just trying to approximate closer to the truth, whatever that truth is." In principle, science depends on cumulative knowledge, but even then these other studies can still tell us something because they map a universe,. The second school of thought is that it is a tool to look at the Cumulative Evidence.

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