Poor Sleep Ages Your Brain

Upgrade your week in just 10 minutes with D(AI)ve Asprey’s essential rundown on what matters most in longevity, biohacking, AI health tech, and medical freedom. 

This episode covers: 

• Apple Cider Vinegar Myth Busted 

A weight-loss study just got retracted. ACV will not melt fat, but it may blunt glucose spikes or ease digestion when diluted in water before carb-heavy meals. Skip the shots and protect your teeth. 

Source: https://www.sciencedaily.com/releases/2025/10/251001092216.htm 

• NMN Is Back 

The FDA reversal puts NMN back on shelves as a clean NAD precursor. Dave explains why quality, cycling, and stacking with anti-inflammatory strategies make the difference. 

Source: https://www.prnewswire.com/news-releases/renue-by-science-celebrates-fda-reversal-confirming-nmn-is-lawful-for-use-in-dietary-supplements-302573317.html 

• Poor Sleep Ages Your Brain 

Machine learning MRI studies show poor sleep makes your brain biologically older and raises dementia risk. Dave shares the three dials to track (deep sleep, REM, resting heart rate) and the three biggest levers to fix them. 

Source: https://www.sciencedaily.com/releases/2024/10/241023171543.htm 

• Psilocybin for Lasting Reset 

New research finds a single guided dose can unlock plasticity, ease pain patterns, and lift mood for weeks. Dave outlines safe protocols, integration steps, and why it is a strategic reset tool, not a party trick. 

Source: https://www.sciencedaily.com/releases/2025/06/250616040215.htm 

• AI Detects Cancer Earlier 

A new AI tool called DOLPHIN can find hidden genetic markers to flag cancer risk sooner. Pairing high tech scans with low tech terrain fixes like sleep, muscle, and insulin control is the prevention model that works. 

Source: https://www.sciencedaily.com/releases/2025/10/251001092206.htm 

All source links provided for easy reference to the original reporting and research above.  

This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Apple cider vinegar, weight loss myths, NMN supplements, NAD precursors, cellular energy, sleep and dementia, brain aging, deep sleep optimization, REM sleep, psilocybin therapy, BDNF, neuroplasticity, pain relief, mood reset, AI cancer detection, early cancer screening, biohacking news, longevity science, Dave Asprey, Human Upgrade podcast 

Thank you to our sponsors!  

• Screenfit | Get your at-home eye training program for 40% off using code DAVE https://www.screenfit.com/dave. 
• LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. 
• Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave. 

Resources:  

• Danger Coffee: https://dangercoffee.com/discount/dave15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

0:00 — Introduction 

0:18 — Story 1: Apple Cider Vinegar and Weight Loss 

1:49 — Story 2: NMN is Back in Supplements 

3:31 — Story 3: Sleep and Brain Health 

5:39 — Story 4: Psilocybin and Lasting Relief 

7:49 — Story 5: AI Tool DOLPHIN for Early Cancer Signals 

9:48 — Conclusion & Weekly Roundup 

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