The Importance of Simulation in Simulation

If you're going to fight a war against a literal God, guess what? You're going to lose. I think the most likely case is that the simulators are indifferent. If we could reach outside of the simulation and kill them all with nanotechnology or whatever, well, then they're not really omnipotent,. Right? They're vulnerable. That's why I feel like it would be a very different situation.