Understanding Histamine Reactions and DAO Levels

214: In this episode, I’m diving into all things histamine—what it is, how it functions, and why it might be the missing link in your hormone and immune health journey. After sharing insights on the connection between histamine sensitivity and hormone replacement therapy (HRT), the response was massive. 

I’m unpacking why histamine issues are more than just food reactions, how they relate to estrogen, menopause, and chronic inflammation, and why there’s no one-size-fits-all solution. I’ve dealt with histamine challenges my whole life and supported countless patients through it.  This episode is a deep, honest look at the bigger picture behind histamine imbalance.

Topics Discussed: 

• What are the symptoms of histamine intolerance and how is it connected to hormone imbalances?

• How does histamine affect estrogen levels and hormone replacement therapy (HRT)?

• What causes high histamine levels and how can you support balance naturally?

• What is the difference between histamine intolerance and mast cell activation syndrome (MCAS)?

• How do lifestyle factors, diet, and gut health influence histamine sensitivity?

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On This Episode Cover: 

• 00:00:00 – Introduction 

• 00:01:57 – Histamine and Your Immune System

• 00:06:01 – Mast Cells, Allergies, and Inflammation

• 00:09:55 – My Personal Histamine Story

• 00:12:38 – Why Histamine Acts Fast

• 00:15:01 – The Role of Histamine in the Body

• 00:19:55 – Histamine Intolerance vs. MCAS

• 00:24:19 – How Menopause Impacts Histamine

• 00:26:32 – Why Your Histamine Is Out of Balance

• 00:28:20 – DAO Deficiency Explained

• 00:32:37 – DAO Blockers and High-Histamine Foods

• 00:34:32 – Lifestyle Stressors and Chronic Illness

• 00:36:19 – Common Mast Cell Triggers

• 00:42:08 – Top High-Histamine Foods

• 00:43:36 – What Are Histamine Liberators?

• 00:44:42 – Estrogen, HRT, and Histamine

• 00:48:10 – Histamine and Metabolic Dysfunction

• 00:48:34 – Recognizing Histamine-Related Symptoms

• 00:51:22 – My Clinical Insights on Histamine

• 00:54:50 – GLP-1 Meds, Histamine, and MCAS

Show Links:

• GLP1 Uncovered
• Find A Doc

Further Listening:

• EP 41: Dangers of NSAIDS - Solo Episode

• EP. 199 | Hot Flashes Are a Warning Sign: The Truth About Metabolic Dysfunction | Quick + Dirty

• EP 106: GLP1 Done Right Part 1 | Solo Episode
  

Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease