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Episode 173: Clinical unknown with Reza and Rabih at VMR: Dyspnea and finger swelling

The Clinical Problem Solvers

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The Role of TNF-alpha Inhibitors in TB

The interferon gamma release assay comes into place for TB. This allows the macrophages start to creating TNF alpha leading to an increase in cytotoxic lymphocytes trying to eradicate the infection, he says. So patients who are given TNF alpha inhibitors are at risk of granulomidus infections and other malignancies like lymphoma.

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