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iwNHL 2023 Session III: Recent updates with the use of antibody-drug conjugates in NHL

VJHemOnc Podcast

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Modulation of Target Antigen and FDA's Changing Requirements for Drug Approval

This chapter discusses the modulation of target antigen in patients with previous CAR-T exposure and the use of different epitopes in ADC-direction CD-19 to prevent loss of CD-19 expression. It also explores the industry perspective on FDA's changing requirements for drug approval and the challenge of demonstrating overall survival advantage in clinical trials for hemolygnancies.

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