In this episode we geek out over research study design. We kick-off the episode with a primer on how research studies work and the factors that strengthen and weaken the validity of a study. We set the stage with a discussion of the "counterfactual" which guides the selection of study design. We talk about how research is hypothesis driven and seeks to address specific, measurable, and answerable questions. We discuss the difference between observational and experimental study designs (and give examples of each) and factors that drive selection of research approach. We spend some time discussing randomized controlled trials (RCTs) and characteristics that strengthen our ability to draw causal conclusions. We talk about clinical trials (and their many phases), and set the stage for next week's episode which will cover the current status of COVID-19 treatments and vaccines.

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Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance.

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