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Ep. 50: “IUIS 2023: Where Immunologists Meet” Featuring Drs. Miriam Merad and Mark Davis

The Immunology Podcast

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PD1 Blockade and Tumor Immune Suppression

You can do latitude by the stars, but you can't do longitude by the stars. You have to have star charts for where they are at a certain time of year and the latitude you're at because it all changes. So we know that the PD1 pathway suppress cytotoxic T cells and prevent killing. We all know it makes fancy new immunotherapy drugs blockade this pathway. Something that they found though is that it's not very consistent across tumor types,. primary versus metastases and other engagements. And there seems to be effects going on that are not just related to suppressing cytot toxic T cells.

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